Question: Remove one Array from another

How do I remove Array B from Array A? e.g.

A:=Array([1,2,3,4,5,6,7,8...1000]
B:=Array([3,6,9,12,15....])   assuming A contains all the elements of B.

to get [1,2,4,5,7,8,11....]

Also is it possible to do it in place?

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